The Best Dog Anxiety Medications (2021 Reviews)

Skylar Dial
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Dog anxiety medications are designed to reduce the symptoms of panic in dogs by instantly creating a calming effect.

There are many different types of anti-anxiety medications for dogs.

Benzodiazepines are probably the most common group of medication prescribed for dogs prone to anxiousness. These medications reduce nervousness, restlessness, sleeplessness, panting, hyperactivity, repetitive movements, and shaking.

According to animal behavior and training expert, Cesar Millan, prescriptions that contain benzodiazepines work well as long as you give them steadily without interruptions.

Millan says that these medications should only be used for short periods of time to reduce the potential for side effects. Giving dogs long-term medication can result in tolerance to the drug, causing the dog to need more to feel the same calming effect. Nervous dogs could also begin to associate certain triggers with the medication and become increasingly anxious when those triggers are present.

NameCategoryProduct
Vetoquinol Zylkene Behavior Support CapsulesBest OverallVetoquinol Zylkene Behavior Support Capsules
Pet Naturals of VermontBudget PickPet Naturals of Vermont
VetriScience Composure Pro Bite Size ChewsUpgrade PickVetriScience Composure Pro Bite Size Chews

1. Vetoquinol Zylkene Behavior Support Capsules

Our rating: 9 / 10

Vetoquinol Zylkene Behavior Support Capsules

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Pros:

  • Lactose-free
  • Soft chews
  • Non-drowsy
  • Very palatable
  • It can also be given to puppies (3 months+)
  • It has a calming effect

(Pack of 180)

In this review we'll be covering a product from Vetoquinol called Zylkene. It's designed to help your dog cope with change and loneliness. Typically formulated to help with anxiety and stress relief. Will help your dog overcome noise-related stress and comfort him during stressful situations.

The Vetoquinol Zylkene Capsules contain natural milk protein‥ and help your dog relax with a softer temperament. It's recommended that you start using Zylkene by administering a small amount. Because it has a pretty good dose of vitamins & minerals.

2. Ready Pet Go! Natural Calming Treats

Our rating: 8 / 10

Ready Pet Go! Natural Calming Treats

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Pros:

  • Great for Separation Anxiety
  • Made 100% in the USA
  • Free Shipping
  • Made With Hemp
  • All Natural
  • Made in the USA
  • 90 Count
  • All Natural and Made in the USA
  • Ingredients: Hemp Hearts, Sunflower Oil, Hemp Extract
  • Customer Service Available to Assist You

Cons:

  • Small, so it may not work for big dogs
  • Small, so you may want to consider larger amounts if you want to offer more
  • Small, so very little goes a long way
  • Some say it doesn’t work that well
  • Some say it’s expensive

The Ready Pet Go! Natural Calming Treats: For Dog Anxiety have the anti-anxiety formula that the CBD, health supplements, and tinctures have for dogs. However, it’s a dog treat, and they are quite pricey.

These treats make life a bit easier for anxious people who experience Potty problems.

3. PREMIUM CARE Calming Treats

Our rating: 8 / 10

PREMIUM CARE Calming Treats

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8 Ounce.

This product is made in the USA, with natural, USDA-certified ingredients. It’s the best calming chew for dogs that we found for separation anxiety.

These easy-to-use treats are tasty, and can be easily wadded up and inserted into a treat dispenser. You’ll get fewer treats than you think (120) with this container, so be prepared to get a refill. Also, locking the container can be tricky at first.

4. Nutri-Vet Pet-Ease Soft Chews

Our rating: 8 / 10

Nutri-Vet Pet-Ease Soft Chews

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Pros:

  • Comes in either chicken flavor or liver and beef flavor
  • It’s affordable
  • It’s easy to administer
  • The package contains a large number of chews (70)

Approved by the FDA, these soft chews can help your pet relax and cope in stressful situations. They also have a calming effect on your pet.

These chews contain GABA, L-Theanine and Taurine – all of which are important for calming nerves.

Since these chews do have some side effects, make sure you talk to your vet before administering them to your dog.

5. MAX Hemp Calming Treats

Our rating: 8 / 10

MAX Hemp Calming Treats

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Crossings, General Anxiety.

6. VetriScience Composure Pro Bite Size Chews

Our rating: 8 / 10

VetriScience Composure Pro Bite Size Chews

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Pros:

  • Easy to administer
  • The effective ingredients are packed into each soft chew
  • Comes at an affordable price
  • Available in flavors that dogs will love
  • No prescription needed
  • Also available in a powder form
  • Available in variety of sizes, from 1-10 bags

Cons:

  • Tylenol is one of the active ingredients towards the end of the ingredient list, so there may be some dogs that will have adverse reactions
  • Some have expressed that it’s not strong enough for really stressed out situations, so may need something stronger

Our top pick as the best dog anxiety medication is the Composure Pro Bite Size Chews for dogs and cats. It’s only fair to tell you that VetriScience manufactures Composure Pro, which is the best-selling anxiety chew on the market to date. It’s also so popular that most pet owners don’t know what the official name of the product is. Just due to the number of 5-star reviews this product has attracted, as well as the positive feedback from dog owners that have tried it, there’s no doubt that this is indeed a good product.

7. Pet Naturals of Vermont

Our rating: 7 / 10

Pet Naturals of Vermont

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Pros:

  • Uses a number of natural substances
  • Plenty of glowing reviews

Overall, this product is a calming supplement that can boost your dog’s immune system and reduce their anxiety. The product comes in a chew format, which aids in soothing and relaxing your dog.

This comes from Natural Dog Company, a company that is dedicated to providing dog owners with the highest quality dog products. The main ingredient in the dog chews is L-Theanine, which reduces the level of stress hormone and calming your dog.

It also contains Caffeine to increase their alertness and anti-anxiety, and also includes a number of minerals. The minerals include Calcium, Magnesium, Potassium and Zinc. The product comes in a pack of 30, and also includes food in their formulation.

8. ThunderEase ThunderEssence Dog Calming Essential Oils

Our rating: 7 / 10

ThunderEase ThunderEssence Dog Calming Essential Oils

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A great natural solution for your pup is ThunderEase. The ThunderEssence formula has been carefully curated to be effective at calming your dog in stressful situations.

The main chemicals include lavender, chamomile, and geranium. These three contain calming, relaxing, and anti-anxiety properties.

An added plus is that the formula is odorless. When mixed with carrier oils, the smell is neutralized.

9. Paws of Kerry Anxiety Relief Calming Treats

Our rating: 7 / 10

Paws of Kerry Anxiety Relief Calming Treats

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Using natural ingredients like Korean Red Ginseng, mint and honey, Paws of Kerry Anxiety Relief Calming Treats for Dogs are designed for use by dogs of all ages. The treats contain a special blend of herbs and vitamins that helps to naturally relieve dog anxiety.

The treats also contain many herbs and vitamins that are great for dog joint wellness support. Amongst other things, they reduce stress levels, promote blood enriching microflora and improve stability of the canine’s immune system.

Although not every dog may enjoy the taste of the anxiety relief chews, the other ingredients may be a hit with your dog. Even if they don’t like the taste, they may enjoy the texture of the treats.

10. POINTPET Calming Treats

Our rating: 7 / 10

POINTPET Calming Treats

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(Calming)

If dogs could use chewables to calm down, they would! Even though these are sold as treats your dog will know better. This natural solution contains calming organic hemp oil and included L-Theanine, an amino acid that is known to have an anxiolytic effect. For those that are interested in dosage it is 25 mg of L-Theanine per treat. You should give your dog one or two treats depending on the size of your dog. Best used prior to the stressful event.

You don’t have to worry that these treats will make your dog drowsy as the calming effect is immediate. If you’re at a loss as to how to properly dose your dog, speak with a professional; there are several for dogs.

11. Vet's Best Comfort Calm Calming Soft Chews Dog Supplements

Our rating: 7 / 10

Vet's Best Comfort Calm Calming Soft Chews Dog Supplements

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Pros:

  • Pets will no longer feel stressed or anxious
  • Veterinarians recommend this product
  • These dog anxiety medication are made with natural ingredients and they can help your dog relax, sleep better and look less stressed
  • This is not a drug
  • It is a supplement designed to make your pets feel much better at any age

Cons:

  • Not advised for puppies under 10 pounds
  • It takes time
  • It may also take months before you see results
  • You must give your dog 2 chewables every day

Some dogs suffer from social anxiety, separation anxiety and more. These dogs hate going for walks, going to the groomers, visiting new places, and when they hear noises or see other animals. Help the dog cope with their anxiety and stop the stress with Vet's Best Comfort Calm Calming Soft Chews Dog Supplements.

12. Richard’s Organics Pet Calm

Our rating: 7 / 10

Richard’s Organics Pet Calm

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Pros:

  • Can also be used for cats and other pets in your home
  • 100% organic and naturally safe
  • Works quickly at soothing your dog
  • Can help your dog with anxiety, hyperactivity, and stress
  • Price – fair pricing for an organic product
  • Made in the U.S.A.
  • 5-star rating on Amazon
  • Provides a cornucopia of benefits for your dog
  • Great to give before taking your pet to the groomers

Cons:

  • Can be difficult to get into smaller dogs; the tabs can be swallowed
  • Not certified organic by the USDA
  • The lid often comes loose
  • Ingredients list is a bit difficult to see

And Erratic Behavior – 4 oz.

Pets. I love them, but they can be challenging … especially when they get older.

They’re often a huge source of joy in our lives, but as they age and start to slow down, they can be temperamental at times. More and more pet owners are finding themselves frustrated with their pets.

13. Adaptil Calming Spray

Our rating: 6 / 10

Adaptil Calming Spray

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Pros:

  • It works instantly
  • Veterinarian recommended
  • It can be used on any breed of dog
  • The price is affordable
  • Can be used on dogs of all ages
  • Safe for use with pregnant dogs and nursing dogs
  • Can be used on dogs with heartworms
  • You don’t need a prescription to purchase this
  • Relieves stress in dogs caused by trips to the vet and other stressful events
  • The spray does not irritate your dog’s nose

Cons:

  • This product has been known to be one of those that work for some but not for others
  • It won’t relieve separation anxiety
  • If your dog gets used to going in the car or simply becomes bored with the spray, it will no longer work
  • It’s not a miracle drug that’s going to instantly calm your pup down

14. Lively Pets Calming Treats

Our rating: 6 / 10

Lively Pets Calming Treats

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Pet owners know how hard it is to calm down their dogs during stressful situations. These treats come in a resealable container and are available in 40 count. The treats come in different sizes, which is great for preventing your dog from choking. The treats themselves are made of natural ingredients, which is much better than the chemical ones. The treats also serve as a great supplement to Calm My Pet Head Bands (see above).

15. Adaptil Dog Calming Diffuser Kit

Our rating: 6 / 10

Adaptil Dog Calming Diffuser Kit

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Pros:

  • The Adaptil spray is great for diffusing in the car
  • The diffuser bottle is small enough to set up on a desk or nightstand
  • The “Puppy Parenting” book is wonderful and very handy
  • The kit itself is super cheap
  • This product is recommended by vets

Cons:

  • The spray itself doesn’t work for every dog
  • The book is good but basic

While still relatively unknown in the US, Adaptil has been used all over the world for well over a decade, as an aid in calming stressed pets.

It’s veterinarian recommended and is a good choice for those with new puppies or a dog with separation anxiety issues.

Adaptil was created to help pets deal with common stressors, like changes in routine, fireworks, thunderstorms, and visits to the veterinarian.

16. Barkbox Veterinarian Formulated Dog Calming Supplement

Our rating: 5 / 10

Barkbox Veterinarian Formulated Dog Calming Supplement

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Pros:

  • All natural ingredients
  • Fast acting, within minutes
  • Clinically proven to reduce anxiety
  • Made in the USA
  • Cheaper than other options
  • Meaty treat, dogs love it

Cons:

  • Can take up to 48 hours to take effect
  • Ensuring your dog eats it can be tricky
  • Contains soy
  • May cause drowsiness

There’s nothing worse than worrying about your dogs anxiety, knowing you have no way of making them feel better. That’s why we’ve done the hard yards and researched a solution for you.

The Barkbox Veterinarian Formulated Dog Calming Supplement for Anxiety Relief is a simple yet effective remedy for dog anxiety and separation anxiety.

This supplement is made from natural ingredients including Tryptophan, Lemon Balm and Green Tea. The primary ingredient is Tryptophan which acts as an antidepressant, calming your pup and has proven to reduce anxiety by as much as 50%.

17. NaturVet Quiet Moments Calming Aid Dog Supplement

Our rating: 5 / 10

NaturVet Quiet Moments Calming Aid Dog Supplement

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It’s not easy to create a relaxing environment for a dog with chronic anxiety. However, NaturVet makes it easier with their dog supplement for motion sickness, storm anxiety, and stress.

The supplement, which is from the company’s semi-moist dog treat range, is easy to use – all you have to do is place the soft chew inside your dog’s mouth and make sure that they give it a good chew. Just by chewing on it for a few minutes, your dog will be able to obtain the level of calming that she or he deserves. Plus, it’s formulated to work immediately for dogs with motion sickness.

The supplement is filled with other ingredients that have been proven to help dogs deal with anxiety and stress – like vitamins, minerals, and amino acids. Plus, it’s even help with dogs who are afraid of thunderstorms.

18. Rescue Remedy Natural Homeopathic Stress Relief Drops

Our rating: 5 / 10

Rescue Remedy Natural Homeopathic Stress Relief Drops

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Pros:

  • Produced from natural ingredients
  • Uses the Bach Flower remedies
  • Non-addictive
  • Easy to use
  • Proven safe effective

Cons:

  • Some dogs don’t like the taste
  • The size of the dropper might not be perfect for small noses
  • Some dogs are not attracted to the liquid, however, if you disguise it with juice then they might take it
  • Some dogs get diarrhea using this remedy
  • Doesn’t seem to work on dogs with separation anxiety.

Ingredient: Homeopathic Flower Remedy for Dogs

The best anxiety medication for dogs is a natural homeopathic remedy called Rescue Remedy. Rescue Remedy is natural, safe and nonaddictive.

The average life expectancy for dogs is 12-16 years, including the ancient hunting dog that lived to 25. But for some dogs it is as little as 5 years.

Frequently Asked Questions (FAQ)

What is the best medication for dogs with anxiety?

Non Selective B-blockers (B1/B2/B3): When the dog is experiencing abnormal brain function due to anxiety, b-blockers can help inhibit the transmission of unneeded impulses to the brain. This medication is rather old and has some dangerous side effects. It isn't on the market in the USA, since it's been off the shelves for years. It is still on sale in some other countries.

Selective B-blockers…(B1/B2/B3): When the dog is experiencing abnormal brain function due to anxiety, b-blockers can help inhibit the transmission of unneeded impulses to the brain. This medication is rather old and has some dangerous side effects. It isn't on the market in the USA, since it's been off the shelves for years. It is still on sale in some other countries.

What are the best calming tablets for dogs?

What is the best pet for anxiety?

I think dogs in general are great for people with anxiety since they offer very unconditional love.

Dogs however are very dependent on routine and also need to be walked every day especially when they are puppies. No matter how much unconditional love they give, they expect that same or more in return.

I have three dogs. My current dog is a great companion for my anxiety because she is quiet and calm. She doesn't need a lot of attention which is good.

I'll soon be adopting another dog and will update the information.

What medication calms dogs down?

While humans go to a psychiatrist, dogs go to a veterinary behaviorist for behavioral and emotional problems. In fact, many of the canine pro-social and calming medications used in behavioral remedies are actually developed for people.

The first step in treating most behavioral and emotional disorders in dogs is conducting a thorough behavioral examination. The behaviorist will break down the problem into four possible categories:

  • Fear
  • Separation
  • Socialization
  • Noise-related

The behaviorist will then begin to treat the dog's problem once the behavior is identified. Dogs can be treated with anti-depressants, sedatives, sleeping medications, hormone treatments, and pain medications.

The most common behavioral medication for dogs, whether prescribed by a veterinarian or taken over the counter, is amitriptyline. Research has shown that it can be very effective in treating dog depression.

Conclusion

We love our dogs and we make sure that they are happy, well-fed, and comfortable. We play with them, go on walks with them, buy them toys, and give them tasty treats. However, sometimes our dogs can get anxious, which can impact our lives. Fortunately, there are a few natural remedies for dog anxiety.

Our Recommendation

NameCategoryProduct
Vetoquinol Zylkene Behavior Support CapsulesBest OverallVetoquinol Zylkene Behavior Support Capsules
Pet Naturals of VermontBudget PickPet Naturals of Vermont
VetriScience Composure Pro Bite Size ChewsUpgrade PickVetriScience Composure Pro Bite Size Chews